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. 2020 Jun 23;140(3):317–339. doi: 10.1007/s00401-020-02178-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Identification of canonical and putative RBP candidates. RNA-binding protein candidates were isolated and identified from the human brain frontal cortical region of 20 cases (spAD, rpAD, sCJD-MM1, sCJD-VV2 as well as controls). a The identified proteomic candidates were searched for RNA-binding annotation in the UniProtKB database. The bar graph is representing two categories. The category I (red) indicates canonical RBPs (known), and category II (black bar) represents potential novel/putative RBP candidates from each group. b Identification of SFPQ-prion-like domain by PLAAC database. The amino acid sequence of SFPQ is represented in colour coded boxes. The red line in the top panel represents the probability of a prion domain against the background. The plots in the middle panel show fold-index scores in grey [60], the log-likelihood (LLR) ratio scores in red [2], and the predicted prion propensity (PPP) in green [81]. Negative scores represent disorder and prion propensity, dashed green line is indicating the cutoff value of PPP > 0.05. The bottom panel is showing the primary sequence of SFPQ with PLD in red colour [2]