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A brief view of EMT and MET. EMT and its reverse process MET occur during physiological and pathological progresses and display a spectral characteristic. During EMT, epithelial cells lost its apical-basal polarity and connections between cells and basement membrane. EMT is regulated by multiple factors, such as transcription factors, cell signaling and epigenetic modification. TJ, tight junction; AJ, adherens junction; DS, desmosome; and HDS, hemidesmosome.
