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Regulation of EMT–MET during reprogramming. Induced pluripotent stem cells (iPSCs) can be accelerated by sequential EMT–MET process. Early EMT can be induced by sequential expression of Yamanaka factors, adding TGF-β or inhibiting of LSD1. These treatments up-regulation of EMT-TFs and also proved metabolic switch from OXPHOS to Glycolysis (OGS). EMT and OGS coordinate to facilitate the reprogramming through an epigenetic regulation way.
