Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 6;8:760. doi: 10.3389/fcell.2020.00760

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Lai, Li, Wu, Lin, Chen, Zheng and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Crosstalk between metabolic and epigenetic regulation. Metabolites from different metabolic pathways participate epigenetic regulation as cofactors. Dioxygenases such as HMTs and DNMTs use SAM as methyl group donor and the reverse demethylation reactions use αKG or FAD to receive the methyl groups. Acetylation of histones is achieved by HATs which transfer acetyl groups from acetyl-CoA. To remove acetyl group from histone proteins, NAD+ is used as a cofactor to support the SIRT activities which belongs to histone deacetylases (HDACs). SAM, S-adenosyl methionine; SAH, S-adenosyl homocysteine; NAD+, oxidized nicotinamide adenine dinucleotide; NAM, nicotinamide; FAD, flavin adenine dinucleotide; αKG, α-ketoglutarate; HMT, histone methyltransferase; HAT, histone acetyltransferase; and SIRT, Sirtuin.