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DNA demethylation and histone demethylation regulate MET process during reprogramming. TET and TDG are essential for early MET through demethylating miR-200 loci and TET1 plays different roles in reprogramming in condition of the present or absent of vitamin C. Passive DNA demethylation through knockdown the expression of Dnmt1 also promote MET. Histone demethylases also regulate MET process in different ways.
