Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 6;10:1230. doi: 10.3389/fonc.2020.01230

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Zhang, Yuan, Peng, Zhou, Jiang, Lin, Yin, Xu, Ma and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

SHP-2 is involved in PDGF-B-induced promotion of TNBC cell proliferation and metastatic phenotype. (A) Activation of the PDGF-B/PDGFR pathway resulted in increased SHP-2 activity. (B,C) The expression of SHP-2 was significantly decreased by siSHP-2 transfection, as indicated by real-time RT-PCR (B) and western blot (C) analyses. (D) The PDGF-B-induced increase in cell growth was inhibited by knockdown of SHP-2. (E,F) The increase in BrdU incorporation (E) and PCNA expression (F) induced by PDGF-B treatment was mitigated by siSHP-2 transfection in TNBC cells. (G,H) The promoting effects of PDGF-B on cell migration (G) and invasion (H) were inhibited by SHP-2 knockdown. *Indicates P < 0.05.