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. 2020 Aug 6;10:1230. doi: 10.3389/fonc.2020.01230

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Copyright © 2020 Zhang, Yuan, Peng, Zhou, Jiang, Lin, Yin, Xu, Ma and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The regulatory effects of PDGF-B/SHP-2 on miR-200a and ZEB1 are mediated by the Akt pathway. (A) The promoting effect of PDGF-B on Akt phosphorylation was reversed by knockdown of SHP-2. (B) The PDGF-B-induced increase in Erk1/2 phosphorylation was mitigated by SHP-2 knockdown. (C,D) Treatment with PDGF-B induced ZEB1 expression (C) and repressed miR-200a expression (D); however, these effects were antagonized by inhibition of the Akt pathway with LY294002. (E,F) Activation of Akt via overexpression of the Myr-Akt mutant promoted ZEB1 expression (E) and repressed miR-200a expression (F) in TNBC cells. *Indicates P < 0.05.