Fig. 1.

Time to progression or recurrence (TTP) of the 528 patients in the cohort stratified for CDKN2A/B homozygous deletion vs. WHO grade (a, b). Forest plot of univariable (unadjusted) hazard ratios for TTP for CDKN2A/B homozygous deletions stratified by WHO grade, methylation classes, TERT promoter mutation status, sex, age and location (c). AgeT gives age tertiles. IA p value gives p value for test on interaction, i.e., different prognostic effect of CDKN2A/B homozygous deletion in subgroups. MC methylation class, ben benign, int intermediate, mal malignant, F female, M male, TTP time to progression/recurrence