Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 12;10:13661. doi: 10.1038/s41598-020-70602-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Instantaneous depolymerization rates and mechanisms as a function of microtubule composition from simulations. (a) Net length of microtubule lost ∆L, depolymerization loss rate, local number of uncompressed dimers, and heat maps indicating sizes of exposed protofilaments as a function of simulation time elapsed. Local numbers of uncompressed dimers are based on the first full three dimer rows after the ram’s horns. Exposed protofilament lengths are measured starting from the last intact row of the microtubule; horizontal dashed lines indicate observed boundaries of ram’s horns. Downward (upward) red triangles highlight instances of large depolymerization rates (low numbers of uncompressed dimers) for 20% and 40% uncompressed. (b,c) Model microtubule configurations before and after an interruption for 20% uncompressed, corresponding to the dashed lines in (a). Red triangles in both panels indicate the intact portion of the microtubule at 1.05 s that defines the three-row region for counting uncompressed dimers shown in brackets.