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. 2020 Aug 12;10:13585. doi: 10.1038/s41598-020-70239-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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P-value uniformity test of ANUBIX, Binox, GEA, GeneSetDP, NEArender and NEAT. 10,000 random gene sets of 110 genes were tested for crosstalk enrichment against the KEGG pathway “Prostate cancer” (A). Reported p-values are plotted against theoretical quantile (rank). A perfect method should adhere to the diagonal. (B) Distributions of the FPR for all KEGG and REACTOME pathways tested with ANUBIX, BinoX, NEArender, NEAT and GEA. Green distribution for enriched tests and red distribution for depleted. The dashed line at FPR = 0.05 denotes the expected FPR level. The black triangle and circle represent the mean FPR for enrichment or depletion respectively. Software: R version 3.4.3 https://www.r-project.org/.