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. 2020 Aug 12;10:13585. doi: 10.1038/s41598-020-70239-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Receiver Operating Characteristic (ROC) curve. For the TP tests, each KEGG and REACTOME pathway is divided into two and a TP is interpreted as the crosstalk between two parts from the same pathway. For the FP tests, 10,000 random gene sets of size 110 are tested for enrichment against KEGG and REACTOME pathways. (A) ROC curve for only the significantly enriched tests (FDR < 0.05). (B) ROC curve for all enriched tests. Software: R version 3.4.3 https://www.r-project.org/.