Table 3.

site and characteristics of radiotherapy treatment and pain and radiological response.

Patient	RT site	Concomitant CDK4/6 inhibitor	RT dose/technique	VNS before RT	VNS at RT end	VNS at 1 mo	Response at 3 mo	Response at 6 mo	LR	Acute toxicity
1	L5 + sacrum + R ilium	Palbociclib	30 Gy/10 fr—3DCRT	6	4	3	SD	SD	No	G3 ileitis
2	L5 + sacrum + R sacroiliac joint	Palbociclib	30 Gy/10 fr—3DCRT	4	4	3		PR	No	G1 diarrhea
3	L femur head; L IX rib	Palbociclib	20 Gy/5 fr—3DCRT	0	0	0		PR	No	None
4	R ischium + R ilium + R femur head + S2; C4; T2	Palbociclib	30 Gy/10 fr—3DCRT	7	5	0	PR	PR	No	G1 sore-throat + G1 diarrhea
5	R ilium + R sacral ala	Palbociclib	20 Gy/5 fr—3DCRT	2	1	0	PR	PR	Yes	None
6	L acetabulum + L femur head; R sacral ala C5 vertebra	Palbociclib	30 Gy/10 fr—3DCRT 30 Gy/3 fr—Tomo	8 0	5 0	0 0		CR PR	No No	G1 nausea + G1 fatigue None
7	Sacrum + R ilium + bilateral femur head	Palbociclib	20 Gy/5 fr—VMAT	7	4	2			No	None
8	T7 vertebra; T12 vertebra; S3-S5 tract	Ribociclib	30 Gy/5 fr—3DCRT	0	0	0	SD	PR	No	G1 nausea
9	T6 vertebra	Ribociclib	20 Gy/5 fr—3DCRT	5	3	0		SD	No	G1 fatigue
10	T2-T4 vertebral tract	Palbociclib	20 Gy/5 fr—3DCRT	6	6	0	SD		No	None
11	T4 vertebra; T9 vertebra; R acetabulum	Ribociclib	20 Gy/5 fr—3DCRT	3	0	0	SD	PR	No	G1 esophagitis
12	T2 vertebra	Palbociclib	20 Gy/5 fr—3DCRT	0	0	0	PR	PR	No	None
13	L ischium + L pubic bone	Ribociclib	8 Gy/1 fr—3DCRT	0	0	0	PR		No	None
14	sternum	Ribociclib	8 Gy/1 fr—3DCRT	2	2	0			No	None
15	T4 vertebra	Abemaciclib	8 Gy/1 fr—3DCRT	0	0	0	PR		No	None
16	L femur	Ribociclib	8 Gy/1 fr—3DCRT	4	4	0	SD	PR	No	None
17	T10-L1 vertebral tract	Abemaciclib	8 Gy/1 fr—3DCRT	5	5	0			No	None
18	sternum	Abemaciclib	30 Gy/3 fr—VMAT	0	0	0			No	None

VNS, pain verbal numeric scale; mo, months; LR, local recurrence; L, left; R, right; fr, fraction; 3DCRT, 3D conformal radiotherapy; Tomo, Tomotherapy; VMAT, Volumetric Modulated Arc Therapy; SD, stable disease; PR, partial response.