Table 1.

Values of model parameters

Parameter	Value	Unit	Reference
${\text{MW}}_{\mathrm{H}}$	1	$\text{g}{\text{mol}}^{-1}$	–
${\text{MW}}_{{\mathrm{CO}}_2}$	44	$\text{g}{\text{mol}}^{-1}$	–
${\text{MW}}_{{\mathrm{O}}_2}$	32	$\text{g}{\text{mol}}^{-1}$	–
${\text{MW}}_{{\mathrm{HCO}}_3}$	61	$\text{g}{\text{mol}}^{-1}$	–
${\text{MW}}_{\mathrm{AcL}}^{\mathrm{a}}$	90.1	$\text{g}{\text{mol}}^{-1}$	–
${\text{P}}_{{\mathrm{M},\mathrm{CO}}_2}^{\mathrm{b}}$	$3.2\times {10}^4$	$\mathrm{\mu }\text{m}{\text{s}}^{-1}$	17
gAcL	$3.8\times {10}^{-4}$	$\text{pg}{\text{s}}^{-1}$	6
${\text{qO}}_2$	$3.5\times {10}^{-5}$	$\text{pg}{\text{s}}^{-1}$	6
${\text{k}}_1$	0.144	${\text{s}}^{-1}$	18
${\text{k}}_2$	$1.9\times {10}^5$	${\text{M}}^{-1}{\text{s}}^{-1}$	18
${\text{V}}_{\text{maxAcL}}$	$9.58\times {10}^{-5}$	$\text{pg}{\text{s}}^{-1}\mathrm{\mu }{\text{m}}^{-2}$	8
${\text{K}}_{\text{mAcL}}$	$0.405\times {10}^{-3}$	$\text{pg}\mathrm{\mu }{\text{m}}^{-3}$	8
${\text{a2c}}_{\text{H}}$_slope	1.5	–	8
${\text{a2c}}_{\text{H}}$_thr	7	–	8
${\text{c2a}}_{\text{H}}$_slope	1.5	–	8
${\text{c2a}}_{\text{H}}$_thr	7	–	8
${\text{V}}_{\text{maxNHE}}$	$5.15\times {10}^{-7}$	$\text{pg}{\text{s}}^{-1}\mathrm{\mu }{\text{m}}^{-2}$	Fit of data in9
${\text{K}}_{\text{mNHE}}$	$0.196\times {10}^{-6}$	M	Fit of data in9
h	2.67	–	Fit of data in9
${\lambda }_{\text{NHE}}$	0.076	–	Fit of data in9
${\text{pH}}_{\text{0,NHE}}$	7.1	–	Fit of data in9
${\text{V}}_{\text{maxTHCO3}}$	$2.02\times {10}^{-5}$	$\text{pg}{\text{s}}^{-1}\mathrm{\mu }{\text{m}}^{-2}$	Fit of data in19
${\text{K}}_{\text{mTHCO3}}$	$7.38\times {10}^{-3}$	M	Fit of data in19
${\lambda }_{\text{THCO3}}$	1.63	–	Fit of data in9
${\text{pHe}}_{\text{0,THCO3}}$	6.85	–	Fit of data in9
${\gamma }_{\text{THCO3}}$	4.2	–	Fit of data in10
${\text{pHi}}_{\text{0,THCO3}}$	6.90	–	Fit of data in10
${\text{V}}_{\text{maxCA9}}$	$9.47\times {10}^{-2}$	$\text{pg}{\text{s}}^{-1}\mathrm{\mu }{\text{m}}^{-2}$	20
${\text{K}}_{\text{mCA9}}$	$7.2\times {10}^{-3}$	M	21
${\delta }_{\text{CA9}}$	7.3	–	Fit of data in22

${}^{\mathrm{a}}$ AcL=lactic acid/lactate.

${}^{\mathrm{b}}$ Parameter values have been determined and fixed as described in the Supplementary Material section