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. 2020 Aug 6;8:687. doi: 10.3389/fcell.2020.00687

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Copyright © 2020 Taubenberger, Baum and Matthews.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mitotic rounding in tissues and tumoroids. Examples of mitotic cells rounding while surrounded by other cells (A) in a non-transformed confluent epithelial cell monolayer (MCF10A) plated on a soft polyacrylamide hydrogel, stained with phalloidin-TRITC to visualize actin (cyan) and DAPI to visualize DNA (Gray) (Image by HM), (B) in vivo in a mitotic sensory organ precursor cell (labeled with LifeAct-GFP in cyan) in the notum of the developing Drosophila pupa. The whole tissue is labeled with tubulin (gray) to stain the mitotic spindle. (Image by Nelio Rodrigues) and (C) frozen section of an MCF-7 tumor spheroid grown for 14 days within a PEG/heparin hydrogel in 3D, stained with phalloidin-TRITC (cyan)/DAPI(gray) for F-actin/nuclei (image by AT). Scale bars are 10 μm.