Figure 1.

V family and J gene usage changes in early childhood. (A) V1 family usage was significantly reduced in older compared with younger individuals in all IgH repertoires. (B) J6 gene usage significantly decreased during the first 10 years of life mostly in IgG subsets. (C) Mean junction length significantly decreased in the first 10 years of life exclusively in IgG subsets. Comparison of each age group to the 0–3y group was performed using the Wilcoxon test. *p < 0.05, **p < 0.01, ***p < 0.001.