Table 4.
Other organ autoimmunity and autoimmune diseases among DMT1 patients aged 0–18 years diagnosed in years 2010–2018.
| Annual distribution | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Year | Total | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | χ2 and p-value total | χ2 and p-value 2010 vs. 2018 |
| T1D, n | 493 | 48 | 54 | 50 | 54 | 57 | 51 | 43 | 61 | 72 | ||
| TAI, n (%) |
66 (13.5) |
8 (16.6) |
10 (18.5) |
9 (18.0) |
8 (14.8) |
6 (10.5) |
6 (11.8) |
4 (9.3) |
5 (8.2) |
10 (13.8) |
χ2 = 5.2 p = 0.7 |
χ2 = 2.3 p = 0.12 Y = 1.6 p = 0.19 Fi p = 0.09 |
| TTGA, n (%) |
38 (7.8) |
5 (10.4) |
7 (13.7) |
1 (1.9) |
3 (5.6) |
6 (10.5) |
3 (5.9) |
2 (4.6) |
4 (6.5) |
7 (9.8) |
χ2 = 7.8 p = 0.45 |
χ2 = 0.4 p = 0.50 Y = 0.09 p = 0.70 Fi p = 0.30 |
| AI, n (%) |
99 (20.1) |
12 (25) |
15 (27.7) |
10 (18.8) |
10 (18.5) |
11 (19.3) |
9 (17.6) |
6 (13.9) |
9 (14.7) |
17 (23.6) |
χ2 = 5.7 p = 0.68 |
χ2 = 1.2 p = 0.26 Y = 0.7 p = 0.37 Fi p = 0.18 |
| AITD, n (%) |
37 (7.5) |
3 (6.25) |
2 (3.7) |
7 (13.2) |
5 (9.3) |
3 (5.3) |
3 (5.9) |
3 (7) |
2 (3.3) |
9 (12.5) |
χ2 = 8.7 p = 0.36 |
χ2 = 1.2 p = 0.20 Y = 0.6 p = 0.40 Fi p = 0.20 |
| CD, n (%) |
26 (5.3) |
2 (4.2) |
1 (1.8) |
1 (1.9) |
1 (1.8) |
6 (10.5) |
2 (3.9) |
2 (4.6) |
4 (6.7) |
7 (9.8) |
χ2 = 10.4 p = 0.2 |
χ2 = 1.3 p = 0.20 Y = 0.6 p = 0.42 Fi p = 0.21 |
| AAD, n (%) |
61 (12.4) |
5 (10.4) |
3 (5.6) |
8 (15.1) |
6 (11.1) |
8 (14.0) |
5 (9.8) |
5 (11.6) |
6 (9.8) |
15 (20.8) |
χ2 = 8.5 p = 0.38 |
χ2 = 2.7 p = 0.09 Y = 1.9 p =1.50 Fi p = 0.07 |
n, no. of patients; X2 - Chi-squared; Y, Yates correction; Fi, Fisher exact test; T1D, type 1 diabetes mellitus; TAI, thyroid-positive autoimmunity; TTGA, anti-tissue transglutaminase antibodies positive; AI, autoimmunity (thyroid + celiac); AITD, autoimmune thyroid disease; CD, celiac disease; AAD, additional autoimmune disease (total).