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Reagents and conditions: (i) THF, NaOH, NaClO, 0°C, 2 h; (ii) DMF, THP, Pyruvic aldehyde dimethyl acetal, 45°C, 24 h; (iii) HCl, 60°C, 12 h; (iv) 2-iminothiazolidin-4-one, ethanol, ammonium acetate, glacial acetic acid, reflux, 24 h; (v) Toluene, thioglycollic acid, ammonium carbonate, reflux, 18 h; (vi) Methanol, aromatic amine/cyclopropylamine, rt, 30 min; (vii) Thioglycollic acid, toluene, 85°C, reflux, 8 h.
