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Results of macrophage assay.
| Compounds | EC90 (μg/mL)a | EC99 (μg/mL)a | EC90/MICb |
|---|---|---|---|
| 2t | 1.66 | 5.25 | 1.06 |
| 2u | 0.84 | 3.27 | 0.54 |
| 2y | 1.33 | 4.58 | 0.85 |
| 2z | 0.92 | 3.93 | 0.59 |
EC90 and EC99 are defined as the concentrations causing 90 and 99% reductions in residual mycobacterial growth after 7 days as compared to untreated controls.
Compounds with EC90 > 16*/MIC are considered inactive.
