TABLE 2.
Frequencies of human leukocyte antigen (HLA)-DRB1 alleles in patients with hypersensitivity pneumonitis with and without autoantibodies (HPAbs+ and HPAbs−, respectively)
| Hypersensitivity pneumonitis | HPAbs+ | HPAbs− | p-value | OR (95% CI) | ||||
| Patients | AF % | Patients | AF % | Patients | AF % | |||
| Patients | 170 | 60 | 110 | |||||
| *01 | 17 | 5.000 | 5 | 4.167 | 12 | 5.455 | 0.79 | 0.74 (0.24–2.21) |
| *03:01 | 14 | 4.118 | 13 | 10.833 | 1 | 0.455 | 1.65×10-4# | 30.14 (3.83–237.1) |
| *04 | 70 | 20.588 | 21 | 17.500 | 49 | 22.273 | 0.25 | 0.67 (0.34–1.28) |
| *07 | 22 | 6.471 | 9 | 7.500 | 13 | 5.909 | 0.63 | 1.31 (0.52–3.28) |
| *08 | 71 | 20.882 | 24 | 20.000 | 47 | 21.364 | 0.74 | 0.89 (0.47–1.69) |
| *09 | 4 | 1.176 | ND | 4 | 1.818 | |||
| *10 | 5 | 1.471 | ND | 5 | 2.273 | |||
| *11 | 24 | 7.059 | 6 | 5.000 | 18 | 8.182 | 0.35 | 0.56 (0.21–1.51) |
| *12 | 2 | 0.588 | ND | 2 | 0.909 | |||
| *13 | 23 | 6.765 | 10 | 8.333 | 13 | 5.909 | 0.48 | 1.49 (0.61–3.64) |
| *14 | 59 | 17.353 | 18 | 15.000 | 41 | 18.636 | 0.4 | 0.72 (0.36–1.41) |
| *15 | 14 | 4.118 | 8 | 6.667 | 6 | 2.727 | 0.08 | 2.66 (0.87–8.08) |
| *16 | 15 | 4.412 | 6 | 5.000 | 9 | 4.091 | 0.77 | 1.24 (0.42–3.68) |
Data are presented as n, unless otherwise stated. AF: allele frequency; ND: not detected. #: p-value after Bonferroni's correction for the total alleles (n=20) identified in both loci. The comparison was made between HPAbs+ versus HPAbs− groups.