TABLE 5.
Univariate analysis adjusting the risk allele (DRB1*03:01) by diffusing capacity of the lung for carbon monoxide (DLCO) and C-reactive protein (CRP)
| Nonsurvivors | Survivors | cOR (95% CI) | p-value | Model 1 aOR (95% CI) | p-value | Model 2 aOR (95% CI) | p-value | Model 3 aOR (95% CI) | p-value | |
| Patients# | 21 | 141 | ||||||||
| Age at baseline evaluation years | 52.8±9.9 | 52.6±11.3 | 1.0 (0.96–1.04) | 0.94 | ||||||
| Male | 6 (29) | 22 (16) | 2.1 (0.75 –6.10) | 0.15 | ||||||
| DRB1*03:01 | 4 (19) | 7 (5) | 4.5 (1.19–16.90) | 0.026 | 3.9 (0.69–24.83) | 0.14 | 5.9 (1.05–33.05) | 0.043 | ||
| Current smokers | 4 (19) | 33 (24) | 0.7 (0.23–2.40) | 0.62 | ||||||
| Arterial hypertension | 3 (14) | 26 (20) | 0.6 (0.18–2.40) | 0.54 | ||||||
| Diabetes mellitus | 3 (14) | 20 (15) | 0.9 (0.25–3.40) | 0.91 | ||||||
| Baseline FVC % pred | 48 (32–66) | 53 (41–73) | 0.9 (0.96–1.01) | 0.27 | ||||||
| Baseline DLCO % pred | 26.5 (20–47) | 48.5 (37–64) | 0.9 (0.92–0.98) | 0.006 | 0.94 (0.91–0.98) | 0.008 | 0.94 (0.91–0.98) | 0.007 | 0.94 (0.91–0.98) | 0.006 |
| PO2 mmHg | 50.9±13.1 | 50.8±11.0 | 1.0 (0.95–1.04) | 0.99 | ||||||
| PCO2 mmHg | 33.7 (30.8–36.0) | 35 (32.0–39.9) | 0.9 (0.85–1.02) | 0.13 | ||||||
| PAP¶ mmHg | 42 (31–50) | 35 (25–45) | 1.0 (0.99–1.06) | 0.09 | ||||||
| 6MWT m | 333 (220–400) | 350 (245–434) | 0.9 (0.98–1.00) | 0.48 | ||||||
| CRP mg·dL−1 | 0.52 (0.37–1.16) | 0.43 (0.23–0.84) | 1.6 (1.02–2.55) | 0.037 | 2.09 (1.13–3.86) | 0.02 | 2.2 (1.2–3.9) | 0.01 | 2.03 (1.12–3.6) | 0.02 |
| BAL lymphocytosis % | 40 (33–54) | 47 (30–62) | 0.9 (0.96–1.01) | 0.36 | ||||||
| HRCT chronic pattern | 13 (62) | 91 (61) | 1.03 (0.4–2.65) | 0.94 | ||||||
| HPAbs+ | 12 (57) | 42 (30) | 3.14 (1.23–8.01) | 0.02 | 2.9 (0.83–10.19) | 0.09 | 3.08 (0.88–10.7) | 0.076 |
Data are presented as n, mean±sd, n (%) or median (range), unless otherwise stated. The crude odds ratio (cOR) of the strength of association of DLCO with mortality was estimated with the data of 118 patients. The multivariate logistic regression model was obtained with the data of 103 patients, the goodness of fit of the model is p=0.69, and the area under receiver operating characteristic curve=0.82. HLA DRB1*03 and HP Abs+ were strongly associated (OR 9.52, 95% CI 1.85–92.0), suggesting collinearity between these two variables in model 1. aOR: adjusted odds ratio; FVC: forced vital capacity; PO2: oxygen tension; PCO2: carbon dioxide tension; PAP: pulmonary artery pressure; 6MWT: 6-min walk test; BAL: bronchoalveolar lavage; HRCT: high-resolution computed tomography; HPAbs+: hypersensitivity pneumonitis with and without autoantibodies. #: survival was obtained in 162 out of the 170 patients; ¶: measured by echocardiography.