Table 1.
Clinicopathological features of the four cases with cHCC-CCA.
| Case | 1 | 2 | 3 | 4 |
|---|---|---|---|---|
| Age | 65 | 62 | 67 | 45 |
| Sex | M | M | F | M |
| Background liver disease | HCV-LC | HBV-LC | NASH | Alcoholic LC |
| Child-Pugh | C(11) | C(11) | B(8) | C(10) |
| CEA [ng/mL] | 2.4 | 3.1 | 5 | 11 |
| CA19-9 [U/mL] | 40 | 33.1 | 34.8 | <0.6 |
| AFP [ng/mL] | 85.8 | 6.7 | 2075 | 642.3 |
| DCP [mAU/mL] | 84 | 59 | 380 | 18 |
| Milan criteria | Within | Within | (Beyond→) Within* | Beyond |
| Kyoto criteria | Within | Within | Within | (Within→) Beyond** |
| Tumor number (total) | 3 | 2 | 3 | ＞10 |
| Tumor number (cHCC-CCA) | 1 | 1 | 1 | 1 |
| Tumor size(cHCC-CCA) [cm] | 1.4 | 1.1 | 2.1 | 3.6 |
| Tumor size(maximum) [cm] | 2.9 | 1.1 | 3 | 3.6 |
| Recurrence | – | – | – | Multiple liver cancer |
| Recurrence[month] | – | – | – | 9 |
| Outcome | Alive | Alive | Alive | Death |
| Survival time[month] | 65 | 66 | 11 | 15 |
| Cause of death | – | – | – | Liver cancer |
*Case 3 did not meet the Milan criteria preoperatively. However, she met the criteria on the postoperative examination. ** Case 4 met Kyoto criteria preoperatively, but did not meet Kyoto criteria on the postoperative examination. M: male, F: female, HCV: hepatitis C virus, HBV: hepatitis B virus, NASH: non-alcoholic steatohepatitis, LC: liver cirrhosis.