Figure 6.

LCPAT1 Regulates BC Progression through Activation of MFAP2

(A) Expression value of RBBP4 in BC tissues and normal tissues according to online tool UALCAN. (B) Expression value of RBBP4 in BC tissues and normal tissues according to online tool GEPIA. (C–E) The effects of RBBP4 and MFAP2 on cell proliferation were tested by CCK8 (C), EdU incorporation (D), and colony formation (E) assays. (F and G) Transwell assay was performed to analyze cell migration (F) and invasion (G). (H) Apoptosis was evaluated by measuring the activity of caspase-3. (I–K) Cell proliferation was measured by CCK8 (I), EdU incorporation (J), and colony formation (K) assays after MFAP2 restoration. (L and M) MFAP2 restoration rescued the ability of migration (L) and invasion (M). (N) MFAP2 overexpression decreased the activity of caspase-3. ∗∗∗p < 0.001.