Table 2.
Logistic Regression and Cox Proportional Hazard Results: Bivariate Models
| Prediction of conversion | Prediction of time to conversion | |||||||
|---|---|---|---|---|---|---|---|---|
| Variables | Coef. | SE | OR (95% CI) | Z, p value | Coef. | SE | HR (95% CI) | Z, p value |
| HCV and MMSE | ||||||||
| HCV | −0.92 | 0.16 | 0.40 (0.29–0.54) | −5.67, p < .0001 | −0.53 | 0.08 | 0.59 (0.51–0.68) | −6.89, p < .00001 |
| MMSE | −0.63 | 0.15 | 0.53 (0.39–0.71) | −4.17, p < .0001 | −0.40 | 0.08 | 0.66 (0.57–0.78) | −5.01, p < .0001 |
| HCV: MMSE | −0.35 | 0.17 | 0.71 (0.50–0.98) | −2.05, p < .05 | −0.25 | 0.08 | 0.78 (0.66–0.91) | −3.18, p = .002 |
| HCV and ADAS | ||||||||
| HCV | −0.66 | 0.17 | 0.52 (0.37–0.72) | −3.86, p = .0001 | −0.41 | 0.08 | 0.67 (0.57–0.78) | −5.05, p < .0001 |
| ADAS | 1.18 | 0.19 | 3.26 (2.27–4.83) | 6.16, p < .0001 | 0.64 | 0.08 | 1.91 (1.62–2.25) | 7.79, p < .0001 |
| HCV: ADAS | 0.34 | 0.22 | 1.41 (0.92–2.14) | 1.59, p = .11 | 0.23 | 0.09 | 1.26 (1.07–1.49) | 2.70, p < .01 |
| HCV and FAQ | ||||||||
| HCV | −0.95 | 0.17 | 0.39 (0.27–0.54) | −5.56, p < .0001 | −0.50 | 0.07 | 0.61 (0.53–0.70) | −6.99, p < .0001 |
| FAQ | 1.05 | 0.22 | 2.84 (1.90–4.55) | 4.72, p < .0001 | 0.38 | 0.06 | 1.46 (1.30–1.65) | 6.28, p < .0001 |
| HCV: FAQ | 0.15 | 0.23 | 1.16 (0.73–1.77) | 0.65, p = 0.52 | 0.06 | 0.06 | 1.06 (0.95–1.19) | 1.09, p = 0.28 |
| HCV and RAVLT | ||||||||
| HCV | −0.92 | 0.17 | 0.40 (0.28–0.55) | −5.44, p < .0001 | −0.49 | 0.08 | 0.61 (0.53–0.71) | −6.46, p < .0001 |
| RAVLT | −0.18 | 0.20 | 0.31 (0.21–0.44) | −6.04, p < .0001 | −0.75 | 0.10 | 0.47 (0.39–0.58) | −7.45, p < .0001 |
| HCV: RAVLT | −0.09 | 0.22 | 0.91 (0.59–1.40) | −0.41, p = .68 | −0.17 | 0.84 | 0.84 (0.70–1.01) | −1.84, p = .07 |
Note. MMSE = mini-mental state examination (standardized); ADAS = Alzheimer Disease Assessment Scale (standardized); RAVLT = Rey Auditory Verbal Learning Test (immediate; standardized); FAQ = Functional Assessment Questionnaire (standardized); HCV = hippocampal volume adjusted by age, field strength, and intracranial volume (standardized).