Table 3.
Risk of Conversion from MCI to AD Over Time (Cox Proportional Hazard) by Hippocampal Volume Categories
Variables | Coef. | SE | HR (95% CI) | Z, p Value |
---|---|---|---|---|
MMSE and HCV | ||||
Medium HCV category | −0.59 | 0.18 | 0.55 (0.39–0.79) | −3.29, p = .001 |
Large HCV category | −1.68 | 0.31 | 0.19 (0.10–0.35) | −5.35, p < .0001 |
MMSE | −0.07 | 0.14 | 0.93 (0.70–1.23) | −0.5, p = .61 |
Medium HCV category: MMSE | −0.38 | 0.17 | 0.68 (0.49–0.96) | −2.21, p = .03 |
Large HCV category: MMSE | −0.60 | 0.31 | 0.55 (0.30–1.00) | −1.95, p = .05 |
ADAS and HCV | ||||
Medium HCV category | −2.28 | 0.69 | 0.10 (0.03–0.39) | −3.33, p = .0008 |
Large HCV category | −3.11 | 1.05 | 0.04 (0.01–0.35) | −2.96, p = .003 |
ADAS | 0.03 | 0.03 | 1.03 (0.97–1.08) | 0.94, p = .35 |
Medium HCV category: ADAS | 0.10 | 0.03 | 1.10 (1.04–1.17) | 3.14, p = .003 |
Large HCV category: ADAS | 0.10 | 0.06 | 1.10 (0.99–1.23) | 1.71, p = .09 |
FAQ and HCV | ||||
Medium HCV category | −0.63 | 0.25 | 0.53 (0.33–0.87) | −2.53, p = .01 |
Large HCV category | −2.08 | 0.44 | 0.13 (0.05–0.30) | −4.74, p < .0001 |
FAQ | 0.06 | 0.03 | 1.06(1.00–1.13) | 1.89, p = .06 |
Medium HCV category: FAQ | 0.03 | 0.04 | 1.03 (0.96–1.10) | 0.81, p = .42 |
Large HCV category: FAQ | 0.08 | 0.06 | 1.09 (0.97–1.21) | 1.47, p = .14 |
RAVLT and HCV | ||||
Medium HCV category | 0.82 | 0.66 | 2.27 (0.62–8.28) | 1.25, p = .21 |
Large HCV category | 1.11 | 1.42 | 3.02 (0.19–49.31) | 0.78, p = .44 |
RAVLT | −0.04 | 0.02 | 0.96 (0.93–0.99) | −2.05, p = .04 |
Medium HCV category: RAVLT | −0.04 | 0.02 | 0.96 (0.92–0.99) | −2.01, p = .045 |
Large HCV category: RAVLT | −0.09 | 0.05 | 0.92 (0.83–1.01) | −1.86, p = .06 |
Note. MMSE = mini-mental state examination (standardized); ADAS = Alzheimer Disease Assessment Scale (standardized); RAVLT = Rey Auditory Verbal Learning Test (immediate; standardized); FAQ = Functional Assessment Questionnaire (standardized); HCV = hippocampal volume adjusted by age, field strength, and intracranial volume (standardized).