Table 3.

Risk of Conversion from MCI to AD Over Time (Cox Proportional Hazard) by Hippocampal Volume Categories

Variables	Coef.	SE	HR (95% CI)	Z, p Value
MMSE and HCV
Medium HCV category	−0.59	0.18	0.55 (0.39–0.79)	−3.29, p = .001
Large HCV category	−1.68	0.31	0.19 (0.10–0.35)	−5.35, p < .0001
MMSE	−0.07	0.14	0.93 (0.70–1.23)	−0.5, p = .61
Medium HCV category: MMSE	−0.38	0.17	0.68 (0.49–0.96)	−2.21, p = .03
Large HCV category: MMSE	−0.60	0.31	0.55 (0.30–1.00)	−1.95, p = .05
ADAS and HCV
Medium HCV category	−2.28	0.69	0.10 (0.03–0.39)	−3.33, p = .0008
Large HCV category	−3.11	1.05	0.04 (0.01–0.35)	−2.96, p = .003
ADAS	0.03	0.03	1.03 (0.97–1.08)	0.94, p = .35
Medium HCV category: ADAS	0.10	0.03	1.10 (1.04–1.17)	3.14, p = .003
Large HCV category: ADAS	0.10	0.06	1.10 (0.99–1.23)	1.71, p = .09
FAQ and HCV
Medium HCV category	−0.63	0.25	0.53 (0.33–0.87)	−2.53, p = .01
Large HCV category	−2.08	0.44	0.13 (0.05–0.30)	−4.74, p < .0001
FAQ	0.06	0.03	1.06(1.00–1.13)	1.89, p = .06
Medium HCV category: FAQ	0.03	0.04	1.03 (0.96–1.10)	0.81, p = .42
Large HCV category: FAQ	0.08	0.06	1.09 (0.97–1.21)	1.47, p = .14
RAVLT and HCV
Medium HCV category	0.82	0.66	2.27 (0.62–8.28)	1.25, p = .21
Large HCV category	1.11	1.42	3.02 (0.19–49.31)	0.78, p = .44
RAVLT	−0.04	0.02	0.96 (0.93–0.99)	−2.05, p = .04
Medium HCV category: RAVLT	−0.04	0.02	0.96 (0.92–0.99)	−2.01, p = .045
Large HCV category: RAVLT	−0.09	0.05	0.92 (0.83–1.01)	−1.86, p = .06

Note. MMSE = mini-mental state examination (standardized); ADAS = Alzheimer Disease Assessment Scale (standardized); RAVLT = Rey Auditory Verbal Learning Test (immediate; standardized); FAQ = Functional Assessment Questionnaire (standardized); HCV = hippocampal volume adjusted by age, field strength, and intracranial volume (standardized).