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. 2019 Jan 21;75(7):1393–1402. doi: 10.1093/geronb/gbz011

Table 3.

Risk of Conversion from MCI to AD Over Time (Cox Proportional Hazard) by Hippocampal Volume Categories

Variables Coef. SE HR (95% CI) Z, p Value
MMSE and HCV
Medium HCV category −0.59 0.18 0.55 (0.39–0.79) −3.29, p = .001
Large HCV category −1.68 0.31 0.19 (0.10–0.35) −5.35, p < .0001
MMSE −0.07 0.14 0.93 (0.70–1.23) −0.5, p = .61
Medium HCV category: MMSE −0.38 0.17 0.68 (0.49–0.96) −2.21, p = .03
Large HCV category: MMSE −0.60 0.31 0.55 (0.30–1.00) −1.95, p = .05
ADAS and HCV
Medium HCV category −2.28 0.69 0.10 (0.03–0.39) −3.33, p = .0008
Large HCV category −3.11 1.05 0.04 (0.01–0.35) −2.96, p = .003
ADAS 0.03 0.03 1.03 (0.97–1.08) 0.94, p = .35
Medium HCV category: ADAS 0.10 0.03 1.10 (1.04–1.17) 3.14, p = .003
Large HCV category: ADAS 0.10 0.06 1.10 (0.99–1.23) 1.71, p = .09
FAQ and HCV
Medium HCV category −0.63 0.25 0.53 (0.33–0.87) −2.53, p = .01
Large HCV category −2.08 0.44 0.13 (0.05–0.30) −4.74, p < .0001
FAQ 0.06 0.03 1.06(1.00–1.13) 1.89, p = .06
Medium HCV category: FAQ 0.03 0.04 1.03 (0.96–1.10) 0.81, p = .42
Large HCV category: FAQ 0.08 0.06 1.09 (0.97–1.21) 1.47, p = .14
RAVLT and HCV
Medium HCV category 0.82 0.66 2.27 (0.62–8.28) 1.25, p = .21
Large HCV category 1.11 1.42 3.02 (0.19–49.31) 0.78, p = .44
RAVLT −0.04 0.02 0.96 (0.93–0.99) −2.05, p = .04
Medium HCV category: RAVLT −0.04 0.02 0.96 (0.92–0.99) −2.01, p = .045
Large HCV category: RAVLT −0.09 0.05 0.92 (0.83–1.01) −1.86, p = .06

Note. MMSE = mini-mental state examination (standardized); ADAS = Alzheimer Disease Assessment Scale (standardized); RAVLT = Rey Auditory Verbal Learning Test (immediate; standardized); FAQ = Functional Assessment Questionnaire (standardized); HCV = hippocampal volume adjusted by age, field strength, and intracranial volume (standardized).