Table 5.
Clinicopathological variables in correlation to CNV of KIT gene and its expression level
| CNV of KIT | Expression level of KIT | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristic | Yes N (%) | No N (%) | cP-value | 0 N (%) | 1 N (%) | 2, N (%) | 3 N (%) | P-value | |
| Expression level of KIT | 0 | 9(50) | 20(43.5) | 0.87 | |||||
| 1 | 7(38.9) | 15(23.6) | |||||||
| 2 | 2(11.1) | 9(19.6) | |||||||
| 3 | 0(0) | 2(4.3) | |||||||
| CD34 expression | <20 | 5(27.8) | 23(50) | 0.04 | 12(41.4) | 9(40.9) | 5(45.5) | 2(100) | 0.82 |
| 20-40 | 12(66.7) | 15(32.6) | 12 (41.4) | 11 (50) | 4 (36.4) | 0 (0) | |||
| >40 | 1(5.6) | 8(17.4) | 5(17.2) | 2(9.1) | 2(18.2) | 0(0) | |||
| Histologic grade | I | 1(5.9) | 9(20) | 0.006 | 5(17.2) | 4(19) | 1(10) | 0(0) | 0.89 |
| II | 11(64.7) | 35(77.8) | 21 (72.4) | 14(66.7) | 9(90) | 2 | |||
| III | 5(29.4) | 1(2.2) | 3(10.3) | 3(14.3) | 0(0) | 0(0) | |||
| ER status | Positive | 12(70.6) | 31(68.9) | 1.00 | 18(62.1) | 16(76.2) | 7(70) | 2(100) | 0.62 |
| Negative | 5(29.4) | 14(31.1) | 11(37.9) | 5(23.8) | 3(30) | 0(0) | |||
| PR status | Positive | 8(47.1) | 30(66.7) | 0.24 | 15(51.7) | 14(66.7) | 7(70) | 2(100) | 0.51 |
| Negative | 9(52.9) | 15(33.3) | 14(48.3) | 7(33.3) | 3(30) | 0(0) | |||
| HER2 status | Positive | 8(47) | 21(46.7) | 0.87 | 11(41.4) | 11(57.1) | 3(30) | 2(100) | 0.32 |
| Negative | 9(53) | 24(53.4) | 17(58.6) | 9(42.1) | 7(70) | 0(0) | |||
| Tumor size | <2 cm | 3(18.8) | 2(4.7) | 0.11 | 1(3.7) | 4(20) | 0(0) | 0(0) | 0.20 |
| 2-5cm | 13(81.3) | 41(95.3) | 26(96.3) | 16(80) | 10(100) | 2(100) | |||
| Age | <40 years | 3(17.6) | 5(11.6) | 0.67 | 4(14.8) | 2(9.5) | 2(20) | 0(0) | 0.70 |
| ≥40 years | 14(82.4) | 38(88.4) | 23(85.2) | 19(90.5) | 8(80) | 2(100) | |||
| Histological Type | aIDCA | 17(100) | 40(90.9) | 0.67 | 26(92.9) | 20(95.2) | 9(90) | 2(100) | 0.89 |
| bILCA | 0(0) | 4(9.1) | 2(7.2) | 1(4.8) | 1(10) | 0(0) | |||
| Node status | Positive | 8(50) | 21(48.8) | 1.00 | 13(48.1) | 10(50) | 7(70) | 0(0) | 0.34 |
| Negative | 8(50) | 22(51.2) | 14(51.9) | 10(50) | 3(30) | 2(100) | |||
| Ki67 | Positive | 15(88.2) | 37(82.2) | 0.71 | 23(79.3) | 19(90.5) | 8(80) | 2(100) | 0.69 |
| Negative | 2(11.8) | 8(17.8) | 6(20.7) | 2(9.5) | 2(20) | 0(0) | |||
| Subtype | luminal A | 8(47.1) | 28(62.2) | 0.65 | 13(44.8) | 15(71.4) | 6(60) | 2(100) | 0.74 |
| luminal B | 3(17.6) | 8(17.8) | 7(24.1) | 2(9.5) | 2(20) | 0(0) | |||
| Basal Like | 5(29.4) | 8(17.8) | 7(24.1) | 4(19) | 2(20) | 0(0) | |||
| ERBB2 | 1(5.9) | 1(2.2) | 2(6.9) | 0(0) | 0(0) | 0(0) | |||
| "Annexin V" | Positive | 5(29.4) | 9(20) | 0.50 | 20(69) | 18(85.7) | 8(80) | 2(100) | 0.55 |
| Negative | 12(70.6) | 36(80) | 9(31) | 3(14.3) | 2(20) | 0(0) | |||
| Stage | I | 1(6.3) | 3(7.0) | 0.23 | 1(3.7) | 3(15) | 0(0) | 0(0) | 0.19 |
| II | 11(68.8) | 36(83.7) | 23(85.2) | 13(65) | 10(100) | 1(50) | |||
| III | 4(6.8) | 49(25) | 3(11.1) | 4(20) | 0(0) | 1(50) | |||
aIDCA = Invasive Ductal Carcinoma.
bILCA= Invasive Lobular Carcinoma.
cP-value from Fisher’s Exact Test.
*clinicopathological data of a number of patients not available.