Table 1.

Schedule of visits and assessments.

Assessment	Screening visit: Day –28 to 0a	Baseline visit: Day –7 to 0a	Visit at 3 months	Visit at 12 months	Visit at 24 months	Unscheduled visit (<10 days of relapse)
Informed consent	Xb
Inclusion and exclusion criteria check	X	X
Demography	Yc
Medical history	Y
Height	Y
Weight	Y			Y
Vital signs	Y	X	Y	Y	Y
Bristol Stool Scale		X	X	X	X
Disease assessment: Expanded Disability Status Scale (EDSS)	X		X	X	X	X
Magnetic resonance imaging (MRI): brain	Y			Y	X
Oral swab		X	X	X	X
Stool sample collection for microbiota assessment		X	X	X	X
Blood sampling for immunological assessment		X	X	X	X
Concomitant medication	Y		Y	Y	Y	Y
Adverse events		Y	Y	Y	Y	Y
Food registration by patient		X	X	X	X

^aScreening and baseline visit activities can be performed on the same day.

^bX: study-specific assessment.

^cY: routine assessment.