Table 2.
Effect of selective epidermal growth factor receptor (EGFR) inhibitor AG1478 on echocardiographic and hemodynamic parameters in spontaneously hypertensive rats.
| Control | SHR | SHR+AG1478 | |
|---|---|---|---|
| LVAWd (mm) | 1.59 ± 0.14 | 2.30 ± 0.22# | 1.83 ± 0.23∗ |
| LVAWs (mm) | 2.30 ± 0.23 | 2.75 ± 0.27# | 2.37 ± 0.16∗ |
| LVPWd (mm) | 1.62 ± 0.15 | 2.33 ± 0.22# | 1.93 ± 0.25∗ |
| LVPWs (mm) | 2.42 ± 0.23 | 2.99 ± 0.27# | 2.65 ± 0.16∗ |
| LVIDd (mm) | 6.70 ± 0.58 | 6.93 ± 0.61 | 6.54 ± 0.79 |
| LVIDs (mm) | 4.31 ± 0.56 | 4.45 ± 0.57 | 4.33 ± 0.65 |
| Fractional shortening (%) | 36.22 ± 4.55 | 35.79 ± 4.03 | 34.68 ± 6.78 |
| Ejection fraction (%) | 64.53 ± 5.47 | 67.73 ± 5.79 | 62.75 ± 8.97 |
| AoSP (mmHg) | 122 ± 7.0 | 182 ± 8.7# | 177 ± 8.9 |
| AoDP (mmHg) | 78 ± 6.4 | 105 ± 7.6# | 103 ± 5.6 |
| Heart rate (beats/min) | 350.7 ± 21.6 | 334.2 ± 21.2 | 379.7 ± 30.7 |
| dp/dt max (mmHg/s) | 4.93 ± 0.18 | 3.50 ± 0.17# | 4.52 ± 0.16∗ |
| dp/dt min (mmHg/s) | −4.75 ± 0.13 | −3.42 ± 0.17# | −4.38 ± 0.25∗ |
SHR represents spontaneously hypertensive rats. LVAWd: left ventricular anterior wall thickness during diastole; LVAWs: left ventricular anterior wall thickness during systole; LVPWd: left ventricular posterior wall thickness during diastole; LVPWs: left ventricular posterior wall thickness during systole; LVIDd: LV internal diameter during diastole; LVIDs: LV internal diameter during systole; AoSP: aortic systolic pressure; AoDP: aortic diastolic pressure; dp/dt max: the maximal rate of left ventricular pressure increase; dp/dt min: the maximal rate of left ventricular pressure decrease. Data are expressed as mean ± standard deviation, n = 10. The analytical tests were implemented using one-way ANOVA followed by the post hoc test. #P < 0.05 vs. the control group; ∗P < 0.05 vs. the SHR group.