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. 2020 Aug 12;10:13624. doi: 10.1038/s41598-020-64682-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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m⁶A modification in 3′-UTR of MYCN promotes its interaction with miR-98. (A) Experimental confirmation of the modification mechanism of the interaction of miR-98 with MYCN by m⁶A-RIP. IgG control sample was shown for control. (B) The 3′-UTR of MYCN sequence was analyzed. (C) The AGACU sequence was mutated into AAAUU, AGGCU and GGACU, and the luciferase reporter gene experiments were conducted in the cells of IMR-32 and SK-N-DZ, respectively. (D) m⁶A-RIP test was carried out in 10 pairs of NB tumor tissues and control tissues. real-time PCR was employed to detect the interaction of m⁶A with MYCN. Three independent experiments have been done. At least three samples were included in an independent experiment if it was not specified in the figures.