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. 2020 Aug 12;10:13621. doi: 10.1038/s41598-020-70598-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Close-up view of the active site of human PNPO. Crystallographic structure obtained in the presence of PLP (PDB: 1NRG;⁶). FMN and PLP in the active site are shown as sticks, in orange and yellow colour, respectively. The R225, R227, R116, and E143 residues are shown as sticks. The image was created using PyMOL v1.7.4.5 Edu Enhanced (https://pymol.org/2/).