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. 2020 Jan 14;5:33. doi: 10.1038/s41525-019-0107-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Histogram (black line) of the correlation coefficients between the mutation number in each gene and the total mutation count in all genes across the pan-cancer cohort (Pearson correlation test). The scatter plot (blue dots) indicates mutation counts in 20,969 genes from all samples. b Correlation between mutation counts within the TTN gene (TTN-TMB) and TMB by WES (TMB-WES) for the pan-cancer cohort (n = 10,224) (Pearson correlation test). c Correlation coefficients between TTN-TMB and TMB-WES for 33 tumor types (Pearson correlation test). d Correlation coefficients of TTN-TMB and TMB-WES (Y-axis) and total mutation count (mean) (X-axis) for each tumor type. TMB tumor mutation burden, WES whole-exome sequencing.