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. 2020 Jan 14;5:33. doi: 10.1038/s41525-019-0107-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Mutation frequency adjusted by coding sequence (CDS) length. b Mutation frequency adjusted by CDS among TTN, other FLAGS, and remaining 18581 genes (p-value by paired Wilcoxon rank-sum test). c Mutation frequency adjusted by CDS length and by both CDS length and GC content, and mRNA expression level of the top 11 FLAGS, including TTN in CDS length in the MSI-H group. d Association between mutation frequency and replication time in FLAGS, including TTN.