Table 2.
Associations of Driver Genes, and Other Frequently Mutated Genes (> 5%), with Overall and Recurrence-Free Survival.
| Alteration n (%) | Overall Survival | Recurrence Free Survival | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Median (95% CI), months | 3-year (95% CI), % | Median (95% CI), months | 3-year (95% CI), % | ||||||||
| Wildtype | Altered | Wildtype | Altered | p-value | Wildtype | Altered | Wildtype | Altered | p-value | ||
| KRAS | 262 (93) | 91.0 (34.8–NA) | 38.8 (33.0–45.5) | 61.4 (38.9–96.8) | 53.5 (46.7–61.2) | 0.043 | 21.7 (14.2–76.5) | 12.9 (11.7–15.9) | 32.9 (16.5–65.5) | 19.8 (14.6–26.9) | 0.117 |
| TP53 | 203 (72) | 65.0 (33.0–NA) | 37.4 (32.1–42.8) | 59.0 (47.4–73.5) | 52.0 (44.3–61.0) | 0.035 | 15.1 (12.8–21.7) | 12.5 (10.9–18.1) | 21.2 (12.8–35.3) | 20.9 (15.0–29.1) | 0.352 |
| CDKN2A | 77 (27) | 39.0 (33.0–47.2) | 38.8 (29.1–NA) | 54.5 (47.2–63.0) | 51.7 (38.4–69.6) | 0.846 | 14.2 (12.3–18.6) | 11.7 (8.9–19.2) | 22.1 (16.3–30.1) | 17.8 (9.5–33.3) | 0.244 |
| SMAD4 | 57 (20) | 38.8 (32.4–47.2) | 39.2 (33.3–NA) | 53.8 (46.5–62.1) | 55.0 (41.1–73.6) | 0.375 | 13.2 (11.9–17.3) | 14.6 (10.3–23.6) | 19.9 (14.4–27.6) | 24.5 (14.3–42.1) | 0.594 |
| ARID1A | 26 (9) | 39.0 (33.9–46.3) | 33.3 (14.3–NA) | 54.6 (47.7–62.5) | 48.4 (30.9–75.8) | 0.722 | 14.0 (12.3–18.5) | 10.5 (7.2–24.5) | 22.1 (16.7–29.3) | 9.3 (1.8–48.7) | 0.119 |
| RNF43 | 20 (7) | 37.6 (33.2–45.5) | NR | 53.1 (46.2–61.0) | 61.7 (42.8–88.9) | 0.178 | 13.7 (12.0–17.6) | 15.5 (9.8–NA) | 21.5 (16.2–28.6) | 12.0 (2.4–60.5) | 0.708 |
| PTPRT | 13 (5) | 39.0 (33.3–47.2) | 34.8 (21.3–NA) | 54.9 (48.2–62.5) | 40.0 (17.8–89.6) | 0.428 | 14.0 (12.0–17.9) | 5.7 (3.2–NA) | 22.1 (16.8–29.1) | NA | 0.019 |
*
NR: median survival not reached