Table 3.

Univariate and Multivariate Analyses of Association between Genomic Alterations and Pathologic Variables with OS.

	Univariate Analysis		Multivariate Analysis
	HR (95% CI)	p-value	HR (95% CI)	p-value
KRAS Alteration	2.29 (1.00–5.22)	0.049	1.74 (0.75–4.01)	0.2
TP53 Alteration	1.54 (1.03–2.31)	0.037	1.54 (1.02–2.33)	0.042
AJCC Stage (8th Edition)		<0.001		0.002
I–II	Ref		Ref
III–IV	1.89 (1.33–2.69)		1.78 (1.23–2.57)
Lymphovascular Invasion	1.73 (1.16–2.59)	0.007	1.96 (1.26–3.04)	0.003
Perineural Invasion	1.33 (0.68–2.63)	0.41
Tumor Size	1.06 (0.94–1.20)	0.36
Neoadjuvant therapy	1.96 (1.33–2.87)	<0.001	2.66 (1.77–4.01)	<0.001
Lymph Nodes	1.20 (0.82–1.75)	0.34