Table 4.
Cumulative Incidence of Site of First Recurrences for KRAS and TP53 Alterations.
| KRAS Alteration | KRAS Wildtype | p-value | |||
|---|---|---|---|---|---|
| 1-year | 3-year | 1-year | 3-year | ||
| Distant only | 28.8 (23.4–34.5) | 42.4 (35.7–48.9) | 10.0 (1.6–27.8) | 22.0 (6.3–43.0) | 0.056 |
| Liver only | 23.3 (18.3–28.7) | 29.7 (23.9–35.6) | 0 (0–0) | 5.8 (0.3–24.5) | 0.013 |
| Local only | 7.2 (4.4–10.8) | 21.6 (16.2–27.7) | 5.0 (0.3–21.2) | 22.3 (6.3–44.3) | 0.356 |
| Local + Distant | 9.9 (6.6–14.0) | 14.2 (10.1–19.0) | 10.0 (1.6–27.8) | 23.1 (6.4–45.9) | 0.669 |
| KRAS G12D | Other KRAS mutation | p-value | |||
| 1-year | 3-year | 1-year | 3-year | ||
| Distant only | 37.1 (27.9–46.3) | 49.9 (38.7–60.1) | 23.2 (16.7–30.4) | 37.0 (28.5–45.6) | 0.039 |
| Liver only | 26.7 (18.6–35.4) | 32.8 (23.9–42.0) | 21.2 (14.9–28.1) | 27.7 (20.2–35.6) | 0.268 |
| Local only | 5.7 (2.3–11.3) | 16.0 (8.8–25.0) | 8.3 (4.5–13.5) | 25.3 (17.6–33.7) | 0.089 |
| Local + Distant | 8.6 (4.2–14.9) | 13.7 (7.8–21.2) | 11.0 (6.5–16.7) | 14.6 (9.2–21.3) | 0.906 |
| TP53 Alteration | TP53 Wildtype | p-value | |||
| 1-year | 3-year | 1-year | 3-year | ||
| Distant only | 28.9 (22.7–35.3) | 39.7 (32.3–47.0) | 23.8 (14.8–33.9) | 43.0 (30.6–54.8) | 0.751 |
| Liver only | 25.8 (19.9–32.1) | 30.7 (24.1–37.5) | 10.5 (4.9–18.7) | 20.6 (12.1–30.7) | 0.084 |
| Local only | 8.7 (5.2–13.1) | 22.4 (16.1–29.3) | 2.7 (0.5–8.4) | 19.7 (10.9–30.4) | 0.875 |
| Local + Distant | 10.7 (6.8–15.5) | 14.6 (9.9–20.2) | 7.9 (3.2–15.4) | 16.1 (8.3–26.2) | 0.862 |
| TP53 Truncation | TP53 Mut, No Truncation | p-value | |||
| 1-year | 3-year | 1-year | 3-year | ||
| Distant only | 26.6 (15.4–39.1) | 37.5 (22.7–52.2) | 29.2 (22.0–36.8) | 40.4 (31.6–48.9) | 0.505 |
| Liver only | 25.8 (18.9–33.1) | 31.2 (23.5–39.3) | 26.6 (15.4–39.1) | 30.5 (17.2–44.9) | 0.831 |
| Local only | 13.3 (5.8–24.1) | 27.3 (15.1–41.0) | 7.0 (3.6–12.0) | 20.5 (13.4–28.7) | 0.173 |
| Local + Distant | 19.1 (9.7–30.8) | 25.6 (14.3–38.5) | 7.7 (4.1–12.8) | 10.4 (5.9–16.5) | 0.009 |
| TP53 LOH | TP53 Mutation, No LOH | p-value | |||
| 1-year | 3-year | 1-year | 3-year | ||
| Distant only | 34.2 (23.7–44.9) | 41.8 (29.6–53.5) | 24.8 (17.3–32.9) | 38.4 (28.8–48.0) | 0.257 |
| Liver only | 35.5 (24.9–46.3) | 40.5 (29.0–51.7) | 19.6 (13.0–27.3) | 24.5 (16.6–33.1) | 0.017 |
| Local only | 7.9 (3.2–15.4) | 15.1 (7.5–25.2) | 9.4 (5.0–15.6) | 28.1 (19.0–38.0) | 0.079 |
| Local + Distant | 17.1 (9.6–26.4) | 22.2 (13.2–32.7) | 6.0 (2.6–11.4) | 9.1 (4.6–15.6) | 0.030 |
| KRAS/TP53 Co-mutation | KRAS/TP53 Wildtype | p-value | |||
| 1-year | 3-year | 1-year | 3-year | ||
| Distant only | 29.8 (23.4–36.3) | 41.0 (33.4–48.5) | 14.3 (2.1–37.5) | 30.4 (8.4–56.3) | 0.255 |
| Liver only | 26.6 (20.6–33.0) | 31.6 (24.8–38.6) | 0 (0–0) | 8.0 (0.4–32.3) | 0.054 |
| Local only | 8.4 (5.0–12.9) | 21.9 (15.5–28.9) | 0 (0–0) | 14.3 (2.0–37.8) | 0.742 |
| Local + Distant | 10.5 (6.6–15.3) | 14.5 (9.7–20.2) | 7.1 (0.4–28.7) | 26.4 (5.1–55.2) | 0.976 |
*
Displayed as % CIR (95% CI)