Figure 6.

Evaluation of the antinociceptive activity of AA and association with naloxone through the formalin test. Lick time was determined in the first 5 min (A, first stage, neurogenic pain), and the second phase (B, inflammatory pain) was assessed 20 min after the start of the test (20–25 min). The animals were treated with vehicle (VEH, control group), anacardic acid (AA: 25 mg/kg, ip), or morphine (MORP; 5 mg/kg, ip) after 30 min receiving 500 μL/well of carrageenan. The dots represent mean ± SEM (n = 5). *p < 0.05 vs VEH group. (one-way ANOVA followed by the Newman–Keuls test with post hoc test).