Table 4.
Amino acid substitutions of the HA protein in Hulunbuir (H1N1) pdm09 strains compared with that of A/Michigan/45/2015, the WHO-recommended vaccine strain during 2017–2019
| Year | Strains | %AA identity | HA 1 | HA 2 | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 64 | 91 | 127 | 146 | 179 | 181 | 200 | 202 | 204 | 232 | 240 | 267 | 273 | 277 | 288 | 312 | 319 | 341 | 421 | 513 | 523 | |||
| A/Michigan/45/2015(H1N1) | 100.00 | V | S | S | N | N | S | S | T | D | A | R | V | T | N | P | I | K | I | I | N | E | |
| 2017 | A/Hulunbuir/1701/2017(H1N1) | 99.82 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | V | – | – | – |
| 2017 | A/Hulunbuir/1702/2017(H1N1) | 99.65 | – | – | – | – | – | – | P | – | – | G | – | – | – | – | – | – | – | – | – | – | – |
| 2017 | A/Hulunbuir/1703/2017(H1N1) | 99.65 | – | – | – | – | – | – | P | – | – | G | – | – | – | – | – | – | – | – | – | – | – |
| 2018 | A/Hulunbuir/1801/2017(H1N1) | 98.94 | – | R | – | – | – | T | P | – | V | – | Q | – | – | – | – | V | – | – | – | – | – |
| 2018 | A/Hulunbuir/1802/2017(H1N1) | 98.94 | – | R | – | – | – | T | P | – | V | – | Q | – | – | – | – | V | – | – | – | – | – |
| 2018 | A/Hulunbuir/1803/2017(H1N1) | 98.76 | – | R | – | – | S | T | P | – | – | – | Q | – | I | – | – | V | – | – | – | – | – |
| 2019 | A/Hulunbuir/1901/2017(H1N1) | 98.41 | – | R | – | D | – | T | P | I | – | – | A | – | D | S | V | – | – | – | – | – | |
| 2019 | A/Hulunbuir/1902/2017(H1N1) | 98.23 | – | R | – | D | – | T | P | I | – | – | Q | A | – | D | S | V | – | – | – | – | – |
| 2019 | A/Hulunbuir/1903/2017(H1N1) | 97.88 | I | R | L | – | – | T | P | – | V | – | Q | – | – | del | – | V | T | – | M | S | D |
Notes: 2009 H1N1 pandemic numbering.