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. Author manuscript; available in PMC: 2020 Aug 13.
Published in final edited form as: Pharm Res. 2018 Jun 25;35(8):164. doi: 10.1007/s11095-018-2444-z

Table I.

In vivo experimental design.

Group Number Side Week 1* Week 2* Week 3* Week 4
1 8 Left Ligatures,
SIM-PPi		 SIM-PPi Remove Ligatures,
SIM-PPi		 Euthanized
Right Ligatures,
PPi		 PPi Remove Ligatures,
PPi		 Euthanized
2 8 Left Ligatures,
SIM		 SIM Remove Ligatures,
SIM		 Euthanized
Right Ligatures,
Saline		 Saline Remove Ligatures,
Saline		 Euthanized
*

Doses: SIM-PPi (2.56 mg, equiv. 1.5mg SIM), SIM acid (1.56mg, equiv. 1.5mg SIM), PPi (0.26 mg equivalent to PPi content in SIM-PPi). (10 μL injection volume).