Table 2.
Comparisons of quality of life and symptoms between patients and controls: Results from questionnaires
| Score | Patients N = 376 |
Controls N = 188 |
p-value |
|---|---|---|---|
| QLQ-C30 | |||
| QLQ-C30 Global score, median [Q1;Q3] |
94.87 [87.44; 98.72] 11 DM |
94.15 [89.66; 98.21] 4 DM |
0.71 |
|
Global health status/QoL: Worse global health (<=83.3), n(%) |
117 (31.3) 2 DM |
49 (26.5) 3 DM |
0.25 |
| Physical Functioning: score < 100, n (%) |
136 (36.5) 3 DM |
63 (34.1) 3 DM |
0.58 |
| Role Functioning: score < 100, n (%) |
71 (19) 3 DM |
25 (13.5) 3 DM |
0.11 |
| Emotional Functioning: score < 100, n(%) |
204 (54.6) 2 DM |
89 (48.1) 3 DM |
0.15 |
| Cognitive Functioning: score < 100, n(%) |
170 (45.6) 3 DM |
99 (53.5) 3 DM |
0.0799† |
| Social Functioning: score < 100, n (%) |
91 (24.3) 2 DM |
30 (16.3) 4 DM |
0.0332* |
| Fatigue: score > 0, n (%) |
167 (44.7) 2 DM |
84 (45.4) 3 DM |
0.87 |
| Nausea/Vomiting: score > 0, n (%) |
16 (4.3) 2 DM |
6 (3.2) 3 DM |
0.56 |
| Pain: score > 0, n (%) |
86 (23) 2 DM |
61 (33) 3 DM |
0.0131* |
| Dyspnea: score > 0, n(%) |
82 (22) 4 DM |
23 (12.4) 3 DM |
0.0078* |
| Insomnia: score > 0, n (%) |
128 (34.2) 2 DM |
70 (37.8) 3 DM |
0.40 |
| Appetite loss: score > 0, n (%) |
19 (5.1) 4 DM |
11 (6) 3 DM |
0.68 |
| Constipation: score > 0, n (%) |
69 (18.5) 3 DM |
44 (23.8) 3 DM |
0.15 |
| Diarrhea: score > 0, n (%) |
53 (14.3) 5 DM |
24 (13) 3 DM |
0.67 |
| Financial Problems: score > 0, n (%) |
22 (6) 10 DM |
6 (3.3) 5 DM |
0.18 |
| IPSS | |||
| Mild | 254 (72.4) | 141 (78.8) | 0.107 |
| Moderate | 77 (21.9) | 31 (17.3) | |
| Severe |
20 (5.7) 25 DM |
7 (3.9) 9 DM |
|
| IIEF-6 | |||
| Severe erectile dysfunction | 209 (65.5) | 55 (32) | < 0.0001 |
| Moderate dysfunction | 28 (8.8) | 19 (11.2) | |
| Mild to moderate dysfunction | 26 (8.2) | 13 (7.6) | |
| Mild dysfunction | 20 (6.3) | 26 (15.1) | |
| No dysfunction |
36 (11.3) 57 DM |
59 (34.3) 16 DM |
|
| ICIQ-MLUTS | |||
| Voiding score (VS) |
2 [0; 5] 17 DM |
2 [1; 5] 6 DM |
0.78 |
| Incontinence score (IS) |
3 [1; 6] 16 DM |
2 [0; 3] 5 DM |
< 0.0001 |
| Frequency of diurnal urination | 0.0884 | ||
| - 1–6 times per day | 213 (58.4) | 124 (66.3) | |
| - 7–8 times per day | 107 (29.3) | 43 (23) | |
| - ≥9 times per day |
45 (12.3) 11 DM |
20 (10.7) 1 DM |
|
| Frequency of nocturnal urination | 0.99 | ||
| - Never | 74 (20.1) | 33 (17.9) | |
| - 1 time per night | 191 (51.9) | 93 (50.5) | |
| - ≥ 2 times per night |
103 (28) 8 DM |
58 (31.5) 4DM |
|
| HADS Anxiety | |||
| Absence of anxiety | 266 (74.9) | 140 (77.4) | 0.64 |
| Suspected anxiety | 59 (16.6) | 31 (17.1) | |
| Probable anxiety |
30 (8.5) 21 DM |
10 (5.5) 7 DM |
|
| HADS Depression | |||
| Absence of depression | 303 (85.1) | 155 (87.6) | 0.44 |
| Suspected depression | 36 (10.1) | 15 (8.5) | |
| Probable depression |
17 (4.8) 20 DM |
7 (4) 11 DM |
|
| HADS Total score | |||
| Absence of anxio-depressive troubles | 277 (80.8) | 149 (85.6) | 0.17 |
| Presence of anxio-depressive troubles |
66 (19.2) 33 DM |
25 (14.4) 14 DM |
|
Data presented as number (%) or median [IQR] as appropriate. Results presented as number (%) patients in each group with functional scores < 100 and symptom scores as > 0. DM: Data missing; *significant difference (< 5%); †potentially significant difference (5–10%)