Table 3.
Comparisons of quality of life and symptoms between the different medical care of patients: Results from questionnaires
| Score | Active surveillance | Radical prostatectomy | Radiotherapy or Brachytherapy or HIFU or ADT | Combined care | p-value |
|---|---|---|---|---|---|
| QLQ-C30 | |||||
| Summary score QLQ-C30 | 97.44 [94.83; 100] | 95.51 [87.65; 98.72] | 92.31 [87.44; 97.78] | 93.25 [84.44; 98.72] | 0.0192 |
| Global health status/QOL: Poorer global health (<=83.3), n (%) | 6 (15.4) | 58 (31.2) | 18 (34) | 35 (38.9) | 0.0694 |
| Physical Functioning: score < 100, n (%) | 10 (25.6) | 60 (32.3) | 27 (50.9) | 36 (40.5) | 0.0319 |
| Role Functioning: score < 100, n (%) | 5 (12.8) | 37 (19.9) | 11 (20.8) | 17 (19.1) | 0.76 |
| Emotional Functioning: score < 100, n (%) | 18 (46.2) | 102 (54.8) | 28 (52.8) | 53 (58.9) | 0.60 |
| Cognitive Functioning: score < 100, n (%) | 11 (28.2) | 79 (42.7) | 27 (50.9) | 51 (56.7) | 0.0153 |
| Social Functioning: score < 100, n (%) | 5 (12.8) | 46 (24.7) | 12 (22.6) | 28 (31.1) | 0.1671 |
| Fatigue: score > 0, n (%) | 12 (30.8) | 88 (47.3) | 28 (52.8) | 38 (42.2) | 0.1589 |
| Nausea/Vomiting: score > 0, n (%) | 1 (2.6) | 5 (2.7) | 2 (3.8) | 8 (8.9) | 0.1320* |
| Pain: score > 0, n (%) | 9 (23.1) | 42 (22.6) | 12 (22.6) | 23 (25.6) | 0.96 |
| Dyspnea: score > 0, n (%) | 6 (15.4) | 37 (20) | 17 (32.1) | 22 (24.7) | 0.1834 |
| Insomnia: score > 0, n (%) | 10 (25.6) | 60 (32.3) | 20 (37.7) | 36 (40) | 0.36 |
| Appetite loss: score > 0, n (%) | 1 (2.6) | 10 (5.4) | 2 (3.9) | 6 (6.7) | 0.88* |
| Constipation: score > 0, n (%) | 1 (2.6) | 38 (20.5) | 9 (17) | 17 (18.9) | 0.0640 |
| Diarrhea: score > 0, n (%) | 7 (18) | 23 (12.5) | 11 (21.2) | 12 (13.3) | 0.40 |
| Financial Problems: score > 0, n (%) | 2 (5.3) | 11 (6) | 2 (3.9) | 7 (8.1) | 0.80* |
| IPSS | |||||
| Mild | 23 (63.9) | 137 (76.5) | 28 (60.9) | 63 (75) | |
| Moderate | 9 (25) | 37 (20.7) | 13 (28.3) | 15 (17.9) | 0.0730 |
| Severe | 4 (11.1) | 5 (2.8) | 5 (10.9) | 6 (7.1) | |
| ICIQ-MLUTS | |||||
| Voiding score (VS) | 4 [1; 7] | 2 [0; 4] | 3.5 [2; 6] | 3 [1; 5] | 0.0011 |
| Incontinence score (IS) | 3 [0; 4] | 4 [2; 6] | 2 [1;4] | 2 [1.5; 6] | < 0.0001 |
| Frequency of diurnal urination | |||||
| - 1–6 times per day | 22 (56.4) | 106 (59.2) | 30 (55.6) | 51 (58.6) | |
| - 7–8 times per day | 13 (33.3) | 50 (27.9) | 17 (31.5) | 26 (29.9) | 0.99 |
| - ≥9 times per day | 4 (10.3) | 23 (12.9) | 7 (13) | 10 (11.5) | |
| Frequency of nocturnal urination | |||||
| - Never | 7 (18) | 44 (24.3) | 8 (15.1) | 15 (16.9) | |
| - 1 time per night | 19 (48.7) | 89 (49.2) | 23 (43.4) | 55 (61.8) | 0.0925 |
| - ≥ 2 times per night | 13 (33.3) | 48 (26.5) | 22 (41.5) | 19 (21.4) | |
| IIEF-6 | |||||
| No dysfunction | 9 (23.1) | 11 (5.9) | 5 (9.3) | 9 (10) | |
| Mild, Mild to moderate, or Moderate dysfunction | 17 (43.6) | 25 (13.4) | 14 (25.9) | 16 (17.8) | < 0.0001 |
| Severe Erectile dysfunction | 13 (33.3) | 151 (80.8) | 35 (64.8) | 65 (72.2) | |
| HADS | |||||
| HADS anxiety | |||||
| - Absence of anxiety | 31 (81.6) | 124 (71.3) | 42 (82.4) | 64 (74.4) | |
| - Suspected anxiety | 6 (15.8) | 32 (18.4) | 7 (13.7) | 13 (15.1) | 0.49 |
| - Probable anxiety | 1 (2.6) | 18 (10.3) | 2 (3.9) | 9 (10.5) | |
| HADS depression | |||||
| - Absence of anxiety | 33 (86.8) | 145 (81.5) | 44 (89.8) | 75 (88.2) | |
| - Suspected anxiety | 5 (13.2) | 19 (10.7) | 3 (6.1) | 9 (10.6) | 0.1588 |
| - Probable anxiety | 0 | 14 (7.9) | 2 (4.1) | 1 (1.2) | |
| HADS Total score | |||||
| - Absence of anxio-depressive troubles | 33 (86.8) | 130 (76.9) | 40 (85.1) | 69 (83.1) | 0.34 |
| - Presence of anxio-depressive troubles | 5 (13.2) | 39 (23.1) | 7 (14.9) | 14 (16.9) | |
Data presented as number (%) or median [IQR] as appropriate. * Fisher test; Khi2 test otherwise