Table 3.

Univariate and multivariate analysis using a cumulative logistic regression method to predict histologic upgrade to microinvasion and invasion

	Univariate analysis		Multivariate analysis
	Odds ratio (95% CI)	P value	Adjusted Odds ratio (95% CI)	P value
Age (old vs. young)	1.02 (1.00–1.05)	0.070
Biopsy method (US-CNB vs. SVAB)	2.78 (1.28–6.01)	0.009
Nuclear grade (grade 3 vs. grade 1–2)	7.51 (2.38–23.75)	< 0.001
Necrosis (present vs. absent)	1.74 (1.02–2.98)	0.044
ER (absent vs. present)	2.97 (1.63–5.38)	< 0.001
PR (absent vs. present)	3.53 (2.02–6.17)	< 0.001	2.40 (1.29–4.44)	0.006
HER2 (present vs. absent)	2.81 (1.62–4.87)	< 0.001
Ki-67 (high vs. low)	3.44 (1.98–6.00)	< 0.001	2.42 (1.30–4.50)	0.005
Mammographic calcification (present vs. absent)	1.70 (0.96–3.02)	0.072
BPE on MRI (minimal or mild vs. moderate or marked)	1.88 (1.00–3.55)	0.051
MR type of lesion (mass or NME vs. non-visualization)
Mass	8.81 (1.10–70.93)	0.041	8.84 (1.05–74.04)	0.045
NME	11.95 (1.50–95.20)	0.019	11.17 (1.35–92.36)	0.025

CI confidence interval; US-CNB US-guided core needle biopsy; SVAB stereotactic vacuum-assisted biopsy; ER estrogen receptor; PR progesterone receptor; HER2 human epidermal growth factor receptor 2; BPE background parenchymal enhancement; NME non-mass enhancement