Table 3.
Beas-2B Cytotoxicity Summarization
| Filter Status | Time | Treatment | ED50 (μg/cm2) | Potency ED50P/ED50CNT | ||
|---|---|---|---|---|---|---|
| PI- | WST1 | PI- | WST1 | |||
| Unfiltered | 24 | PC | 2.28 | 5.34 | 1.70*** | 1.92*** |
| 24 | PC-CNT | 1.34 | 2.78 | |||
| 24 | PU | > 4.0 | > 4.0 | N.D. | N.D. | |
| 24 | PU-CNT | > 4.0 | > 4.0 | |||
| 48 | PC | 1.90 | 3.52 | 1.98*** | 1.86*** | |
| 48 | PC-CNT | 0.96 | 1.89 | |||
| 48 | PU | > 4.0 | > 4.0 | N.D. | N.D. | |
| 48 | PU-CNT | > 4.0 | > 4.0 | |||
| Filtered | 24 | PC | > 4.0 | > 8.0 | N.D. | N.D. |
| 24 | PC-CNT | > 4.0 | > 8.0 | |||
| 24 | PU | > 4.0 | > 4.0 | N.D. | N.D. | |
| 24 | PU-CNT | > 4.0 | > 4.0 | |||
| 48 | PC | > 4.0 | > 8.0 | N.D. | N.D. | |
| 48 | PC-CNT | > 4.0 | > 8.0 | |||
| 48 | PU | > 4.0 | > 4.0 | N.D. | N.D. | |
| 48 | PU-CNT | > 4.0 | > 4.0 | |||
PI- – Cytotoxicity derived from live-cell imaging
WST1 – Cytotoxicity derived from the WST1 method
ED50 – Modeled deposited dose causing 50% of reported cytotoxicity compared to untreated controls
Potency ED50p/ED50CNT – Relative deposited dose causing 50% of cytotoxicity among pristine incinerated thermoplastic (ED50p) compared to CNT-containing analog (ED50CNT) at the same time point. Potency comparisons across time points were not made
N.D. ED50p/ED50CNT Potency value could not be determined
***p < 0.001 of compared to pristine incinerated thermoplastic at the same time point