Table 5.

Summary of Measured Endpoints – Beas-2B

	Cytotoxicity				Genotoxicity					Mechanistic
Agent	ΔΨm	LDH Release	WST1	Clonogenic Proliferation	yH2AX	(p)-Histone H3	Nuclear Area	EdU Uptake	Cell Cycle Checkpoint	ROS	CYP1
PC	↓	↑	↑↓*	↓	–	–	–	–	–	–	↑
PC-CNT	↓	↑	↑↓*	↓	↑	↓	↑	↓	–	↑	↑
PU	–	–	↑	N.D.	–	–	–	–	–	–	↑
PU-CNT	–	–	↑	N.D.	–	–	–	–	–	–	↑
B[a]P	↓	–	↑	↓	–	–	↑	↓	+	↑	↑

↓ Significant reduction at any tested dose; ↑ Significant increase at any tested dose. – No change at any dose. N.D. Not Determined. *Low depositional dose caused increased metabolism but reduced at higher concentrations