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. 2020 Jun 26;29(14):2395–2407. doi: 10.1093/hmg/ddaa121

Figure 2.

Figure 2

Modulation of polyamine synthesis in a mouse model of TSC. (A) Tsc2 loss in radial glia results in mTORC1 hyperactivation, increased ODC activity and putrescine levels. We investigated the effect on TSC neuropathology following genetic and pharmacologic reduction of ODC. (B) Timelines of pharmacologic and genetic reduction of ODC in Tsc2-RG mice. Top: DFMO treatment (daily I.P. injection of 250 mg/kg DFMO from P10 to P21) of Tsc2-RG mice. Bottom: genetic reduction of Odc1 beginning prior to implantation. Gray shading of timeline bars denotes period of ODC reduction. (C, D) Elevated ODC activity (C) and putrescine levels (D) in Tsc2-RG cortex are reduced by DFMO treatment and Odc1 haploinsufficiency. *P < 0.05.