Figure 4.

Long-term effects of Lztfl1 gene therapy in the P21-rescue group. (A–C) Immunoblot analyses of P21-treated Lztfl1^gt/gt;FLP⁺ mice at 1 month (A), 3 months (B) and 6 months (C) PTI. (D) STX3 and STXBP1 localization in P21-treated Lztfl1^gt/gt;FLP⁺ mice. Retinal sections from untreated Lztfl1^gt/gt mice at P21 are shown on the left as a reference point. Scale bar: 25 μm. (E) Survival of cones in P21-treated Lztfl1^gt/gt;FLP⁺ mice. (F) ERG responses of Lztfl1^gt/gt;FLP⁺ mice treated at P21–25. Others are the same as in Figure 3.