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. 2020 Jun 22;29(14):2337–2352. doi: 10.1093/hmg/ddaa124

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Rescue at a mid-disease stage (P45–49) results in only a temporary and marginal improvement in vision. (A–C) Immunoblot analyses of P45-treated Lztfl1^gt/gt;FLP⁺ mice at 1 month (A), 3 months (B) and 6 months (C) PTI. (D) STX3 and STXBP1 localization in P45-treated Lztfl1^gt/gt;FLP⁺ mice. Retinal sections from 1.5-month-old, untreated Lztfl1^gt/gt mice are shown on the left as a reference point. Scale bar: 25 μm. (E) Survival of cones in P45-treated Lztfl1^gt/gt;FLP⁺ mice. (F) TEM images of the retinas from untreated (left; 2.5 months old) and treated (right) Lztfl1^gt/gt;FLP⁺ mice at 1 month PTI. (G) ERG responses of Lztfl1^gt/gt;FLP⁺ mice treated at P45–49. Others are the same as in Figure 3.

Rescue at a mid-disease stage (P45–49) results in only a temporary and marginal improvement in vision. (A–C) Immunoblot analyses of P45-treated Lztfl1^gt/gt;FLP⁺ mice at 1 month (A), 3 months (B) and 6 months (C) PTI. (D) STX3 and STXBP1 localization in P45-treated Lztfl1^gt/gt;FLP⁺ mice. Retinal sections from 1.5-month-old, untreated Lztfl1^gt/gt mice are shown on the left as a reference point. Scale bar: 25 μm. (E) Survival of cones in P45-treated Lztfl1^gt/gt;FLP⁺ mice. (F) TEM images of the retinas from untreated (left; 2.5 months old) and treated (right) Lztfl1^gt/gt;FLP⁺ mice at 1 month PTI. (G) ERG responses of Lztfl1^gt/gt;FLP⁺ mice treated at P45–49. Others are the same as in Figure 3.