Table 1.
Screen for endocytic–exocytic genes on Drosophila lifespan
| Drosophila homologue | Human gene | Function | Effect on lifespan |
|---|---|---|---|
| Cindr | CD2AP | Actin remodelling | Decreased |
| Clc | CLC | Vesicle formation | Decreased |
| Shi | DYNAMIN | Vesicle scission | None |
| EndoA | ENDOA | Vesicle formation | Increased |
| Eps15 | EPS15 | Vesicle formation | Decreased |
| Iqf | EPSIN | Vesicle formation | Decreased |
| Rab4 | RAB4 | Endocytic recycling | Decreased |
| Rab5 | RAB5 | Plasma membrane to early endosome | Increased |
| Rab7 | RAB7 | Early-to-late endosome | Decreased |
| Rab8 | RAB8 | Endocytic recycling | Decreased |
| Rab10 | RAB10 | Endocytic recycling | Decreased |
| Rab11 | RAB11 | Endocytic recycling | Decreased |
| Rab14 | RAB14 | Endocytosis | None |
| Snap25 | SNAP25 | Vesicle fusion | None |
| nSyb | VAMP2 | Vesicle fusion | None |
Summary table of the effect of overexpression of a number of genes on the lifespan of Aß-expressing flies.