Table 1.
Repeated measurements of biomarker concentrations and estimated ICCs, overall and stratified by sex, BMI and hsCRP.
| Biomarkers | N | Median (IQR) |
ICC (95% CI)∗∗ | ||
|---|---|---|---|---|---|
| First measurement | Second measurement | ||||
| Galectin-1, ng/mL | |||||
| All | 163 | 3.1 (2.7–3.6) | 3.2 (2.8–3.8) | 0.70 (0.61, 0.77) | |
| Sex | Men | 64 | 3.0 (2.6–3.4) | 3.0 (2.8–3.8) | 0.77 (0.64, 0.85) |
| Women | 99 | 3.1 (2.7–3.7) | 3.3 (2.8–3.8) | 0.65 (0.52, 0.75) | |
| pdifference∗ | 0.197 | 0.367 | |||
| BMI | <25 kg/m2 | 67 | 3.0 (2.6–3.2) | 3.1 (2.8–3.5) | 0.45 (0.24, 0.62) |
| ≥25 kg/m2 | 96 | 3.2 (2.7–3.7) | 3.4 (2.9–3.9) | 0.80 (0.71, 0.86) | |
| pdifference∗ | 0.009 | 0.031 | |||
| hsCRP | <1.2 μg/mL | 76 | 3.0 (2.6–3.3) | 3.1 (2.7–3.6) | 0.63 (0.47, 0.75) |
| ≥1.2 μg/mL | 87 | 3.2 (2.8–3.7) | 3.4 (2.9–3.9) | 0.74 (0.63, 0.82) | |
| pdifference∗ | 0.018 | 0.019 | |||
| Haptoglobin, μg/mL | |||||
| All | 168 | 175.0 (139.0–234.0) | 163.5 (137.5–209.5) | 0.67 (0.57, 0.74) | |
| Sex | Men | 69 | 184.0 (144.0–245.0) | 170.0 (140.0–215.0) | 0.55 (0.36, 0.69) |
| Women | 99 | 173.0 (136.0–219.0) | 161.0 (132.0–209.0) | 0.74 (0.63, 0.82) | |
| pdifference∗ | 0.485 | 0.583 | |||
| BMI | <25 kg/m2 | 66 | 158.0 (130.0–195.0) | 156.5 (131.0–190.0) | 0.54 (0.35, 0.69) |
| ≥25 kg/m2 | 102 | 179.5 (147.0–268.0) | 174.0 (140.0–262.0) | 0.72 (0.62, 0.80) | |
| pdifference∗ | 0.013 | 0.083 | |||
| hsCRP | <1.2 μg/mL | 75 | 160.0 (129.0–198.0) | 161.0 (133.0–205.0) | 0.77 (0.65, 0.85) |
| ≥1.2 μg/mL | 93 | 190.0 (153.5–259.0) | 163.5 (141.5–215.0) | 0.57 (0.41, 0.69) | |
| pdifference∗ | 0.008 | 0.543 | |||
| Nesfatin-1, ng/mL | |||||
| All | 163 | 0.3 (0.1–1.5) | 0.3 (0.1–1.6) | 0.89 (0.86, 0.92) | |
| Sex | Men | 63 | 0.3 (0.1–1.3) | 0.3 (0.1–1.5) | 0.84 (0.74, 0.90) |
| Women | 100 | 0.4 (0.1–1.5) | 0.5 (0.1–1.7) | 0.93 (0.90, 0.95) | |
| pdifference∗ | 0.831 | 0.574 | |||
| BMI | <25 kg/m2 | 66 | 0.2 (0.1–1.4) | 0.3 (0.1–1.2) | 0.93 (0.89, 0.96) |
| ≥25 kg/m2 | 97 | 0.4 (0.1–1.5) | 0.3 (0.1–1.7) | 0.86 (0.80, 0.90) | |
| pdifference∗ | 0.207 | 0.206 | |||
| hsCRP | <1.2 μg/mL | 78 | 0.3 (0.1–2.6) | 0.3 (0.1–1.7) | 0.93 (0.89, 0.96) |
| ≥1.2 μg/mL | 85 | 0.4 (0.1–1.3) | 0.3 (0.1–1.3) | 0.85 (0.78, 0.90) | |
| pdifference∗ | 0.917 | 0.834 | |||
∗p value for difference based on Wilcoxon-Mann Whitney test between strata (sex, BMI, hsCRP).
∗∗ICC – intraclass correlation coefficient, based on Box-Cox transformed values of the first and second measurement.
BMI – body mass index; hsCRP – high sensitivity C-reactive protein, IQR – interquartile range.