Table 1.
Step-down latency during SDIA training
| Figure | Behavioral condition | Treatment | Latency (s) (per group) | n | Latency (s) (per condition) | p Value (HAN vs PEX) |
|---|---|---|---|---|---|---|
| 1B | HAN | VEH 5′ | 11.75 ± 2.11 | 8 | 13.34 ± 0.93 | <0.0001 |
| ANI 5′ | 15.00 ± 2.77 | 8 | ||||
| sASO 5′ | 16.88 ± 2.68 | 8 | ||||
| ASO 5′ | 12.88 ± 2.66 | 8 | ||||
| VEH 6 h | 12.25 ± 2.62 | 8 | ||||
| ANI 6 h | 14.00 ± 3.47 | 8 | ||||
| sASO 6 h | 11.88 ± 2.07 | 8 | ||||
| ASO 6 h | 12.13 ± 3.03 | 8 | ||||
| PEX | VEH 5′ | 4.88 ± 0.85 | 9 | 5.68 ± 0.50 | ||
| ANI 5′ | 5.00 ± 0.57 | 9 | ||||
| sASO 5′ | 7.44 ± 2.39 | 9 | ||||
| ASO 5′ | 5.88 ± 1.41 | 9 | ||||
| VEH 6 h | 5.55 ± 1.58 | 9 | ||||
| ANI 6 h | 4.66 ± 1.29 | 9 | ||||
| sASO 6 h | 7.00 ± 1.70 | 9 | ||||
| ASO 6 h | 5.00 ± 1.25 | 9 | ||||
| 1D–I | HAN | 12.67 ± 1.58 | 6 | 0.0132 | ||
| PEX | 5.33 ± 1.85 | 6 | ||||
| 1J | PEX | VEH | 6.22 ± 1.02 | 9 | ||
| ANI | 6.11 ± 1.30 | 9 | ||||
| 2A | HAN | VEH | 13.25 ± 1.27 | 8 | 12.81 ± 0.91 | <0.0001 |
| MUS | 12.38 ± 1.37 | 8 | ||||
| PEX | VEH | 5.12 ± 0.85 | 8 | 5.37 ± 0.52 | ||
| MUS | 5.62 ± 0.65 | 8 | ||||
| 2B | HAN | VEH + VEH | 11.00 ± 1.43 | 8 | 14.98 ± 0.89 | <0.0001 |
| VEH + ANI | 15.63 ± 2.71 | 8 | ||||
| MUS + VEH | 15.13 ± 2.72 | 8 | ||||
| MUS + ANI | 17.13 ± 2.81 | 8 | ||||
| VEH + sASO | 12.63 ± 2.41 | 8 | ||||
| VEH + ASO | 16.25 ± 2.44 | 8 | ||||
| MUS + sASO | 15.38 ± 2.51 | 8 | ||||
| MUS + ASO | 16.75 ± 3.29 | 8 | ||||
| PEX | VEH + VEH | 6.00 ± 1.64 | 8 | 6.08 ± 0.49 | ||
| VEH + ANI | 5.12 ± 0.63 | 8 | ||||
| MUS + VEH | 5.11 ± 0.73 | 9 | ||||
| MUS + ANI | 6.22 ± 1.09 | 9 | ||||
| VEH + sASO | 7.87 ± 2.67 | 9 | ||||
| VEH + ASO | 6.12 ± 1.58 | 8 | ||||
| MUS + sASO | 6.11 ± 1.36 | 9 | ||||
| MUS + ASO | 7.33 ± 1.40 | 9 | ||||
| 2D,E | HAN | VEH | 13.40 ± 2.65 | 5 | 14.40 ± 1.78 | <0.0001 |
| MUS | 15.40 ± 2.58 | 5 | ||||
| PEX | VEH | 3.80 ± 0.66 | 5 | 4.80 ± 0.71 | ||
| MUS | 5.80 ± 1.58 | 5 | ||||
| 3 | PEX | Light OFF/VEH | 6.77 ± 1.913 | 9 | ||
| Light OFF/ANI | 6.00 ± 0.897 | 9 | ||||
| Blue ON/VEH | 5.77 ± 1.362 | 9 | ||||
| Blue ON/ANI | 5.66 ± 0.866 | 9 | ||||
| Yellow ON/VEH | 5.88 ± 1.814 | 9 | ||||
| Yellow ON/ANI | 5.50 ± 1.327 | 10 | ||||
| 4C,D | PEX | No Stim./VEH | 6.80 ± 1.04 | 10 | ||
| No Stim./ANI | 6.90 ± 1.56 | 10 | ||||
| Theta Stim./VEH | 6.50 ± 1.15 | 8 | ||||
| Theta Stim./ANI | 7.25 ± 1.26 | 8 | ||||
| TBS RA/VEH | 6.70 ± 1.484 | 10 | ||||
| TBS RA/ANI | 4.90 ± 0.604 | 10 | ||||
| TBS RA(LFP)/VEH | 6.11 ± 1.160 | 9 | ||||
| TBS RA(LFP)/ANI | 6.00 ± 1.384 | 9 | ||||
| TBS after RA/VEH | 6.60 ± 1.50 | 10 | ||||
| TBS After RA/ANI | 6.30 ± 1.10 | 10 | ||||
| TBS No RA/VEH | 6.66 ± 0.95 | 9 | ||||
| TBS No RA/ANI | 5.88 ± 1.20 | 9 | ||||
| TBS 100 corpus callosum/VEH | 6.16 ± 1.10 | 6 | ||||
| TBS 100 corpus callosum/ANI | 5.66 ± 1.33 | 6 | ||||
| 4E | PEX | No Stim./sASO | 4.77 ± 0.70 | 9 | ||
| No Stim./ASO | 6.33 ± 0.95 | 9 | ||||
| TBS RA/sASO | 5.55 ± 1.40 | 9 | ||||
| TBS RA/ASO | 4.77 ± 0.87 | 9 | ||||
| 5A | HAN | No Stim./VEH | 10.88 ± 1.65 | 8 | ||
| No Stim./ANI | 12.38 ± 1.61 | 8 | ||||
| TBS RA/VEH | 15.67 ± 2.02 | 9 | ||||
| TBS RA/ANI | 13.89 ± 2.70 | 9 | ||||
| TBS RA(LFP)/VEH | 12.11 ± 1.95 | 9 | ||||
| TBS RA(LFP)/ANI | 15.67 ± 2.37 | 9 | ||||
| TBS after RA/VEH | 9.87 ± 1.99 | 8 | ||||
| TBS after RA/ANI | 14.50 ± 1.91 | 8 | ||||
| TBS no RA/VEH | 11.50 ± 2.00 | 8 | ||||
| TBS no RA/ANI | 12.25 ± 1.57 | 8 | ||||
| 5B | HAN | No Stim./sASO | 12.71 ± 1.61 | 7 | ||
| No Stim./ASO | 11.71 ± 2.56 | 7 | ||||
| TBS RA/sASO | 15.00 ± 1.79 | 7 | ||||
| TBS RA/ASO | 11.71 ± 2.48 | 7 |
Step-down latency during SDIA training. Repeated pre-exposure to the SDIA training box decreased step-down latency at training, indicating learning of SDIA-related nonaversive information during pre-expositions, as reported in Radiske et al. (2017). Latencies did not differ between groups for the same behavioral condition. Data are presented as the mean ± SEM and were analyzed using an unpaired t test or one-way ANOVA.