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. 2020 Aug 12;11:352. doi: 10.1186/s13287-020-01869-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Migration and adhesion of MSC. a Migration of MSC is assessed by measuring the percentage of MSC able to migrate through a porous membrane towards (injured) HUVEC. b Adhesion of MSC to HUVEC in static conditions. MSC are added on a confluent monolayer of HUVEC, and the percentage of MSC which adhered after 10, 30, and 60 min is assessed by flow cytometry. c Adhesion of MSC to HUVEC in flow conditions. HUVEC are grown and injured in a flow chamber. MSC were infused 1 time or 2 times during flow or 1 time and recirculated for 10 min. The percentage of MSC which adhered was assessed by flow cytometry. d MSC showed an increased migratory capacity towards injured HUVEC compared to non-injured HUVEC. e MSC show increased adhesion to injured HUVEC compared to non-injured HUVEC. f MSC showed 28% adhesion capacity to injured HUVEC during flow conditions after one or two times infusion. Recirculation of MSC yielded increased adhesion of MSC to injured HUVEC during flow conditions. Significance of the comparison between 1 time infusion and recirculation is shown (n = 5). Results are shown as mean ± SD. **p value < 0.01; *p value < 0.05