TABLE 2.

Cognitive and adaptive functioning scores in boys with XXY and XXYY with below-average compared to average/above-average VMI scores

	VMI Below-Average (score <85)	VMI Average or Above (score 85+)	T-Test p-value
XXY
N	13	49
Age	12.5 (2.45)	11.99 (3.71)	0.645
IQ Mean (SD)
Verbal	78.92 (22.2)	95.98 (14.4)	0.019*
Performance	86.62 (15.0)	104.70 (14.1)	<0.001**
Full Scale	80.62 (20.9)	100.44 (14.9)	<0.001**
Adaptive Functioning Mean (SD)	N=10	N=45
Communication	72.7 (19.6)	87.7 (16.7)	0.016*
Daily Living	80.5 (22.8)	92.1 (16.6)	0.068
Social	82.7 (20.5)	91.2 (18.3)	0.201
Adaptive Composite	78.4 (19.7)	89.2 (16.5)	0.075
XXYY
N	22	24
Age	15.0 (4.0)	11.7(4.3)	0.010*
IQ Mean (SD)
Verbal	74.2 (14.0)	77.5 (14.8)	0.434
Performance	84.7 (13.9)	89.2 (12.0)	0.247
Full Scale	76.4 (13.2)	83.2 (15.8)	0.122
Adaptive Functioning Mean (SD)	N=20	N=22
Communication	54.7 (16.8)	72.3 (19.3)	0.003**
Daily Living	68.9 (10.5)	78.6 (15.5)	0.021*
Social	70.8 (11.8)	79.1 (13.5)	0.040*
Adaptive Composite	67.7 (7.27)	75.6 (13.3)	0.024*

^*p<0.05 for T-test comparing groups with low versus average VMI scores.

^**p<0.007 for t-tests comparing between low versus average VMI scores (Bonferroni correction for multiple comparisons)